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  1. #1
    Senior Member Aintdealingwithyoshit's Avatar
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    Lightbulb [Lifestyle] Nootropics

    Is anyone here taking or interested in Nootropics? Personally I've been growing more interested in the topic as of late, after all the number one "muscle" in today's society is the brain (despite the many horrendously asinine people out there).
    I've come across a very cheap but apparently rather effective Nootropic called Uridine, which actually promotes neuronal growth (imo the most important part of a Nootropic, screw neuroprotection and memory improvement ) AND on top of that appears to also improve liver health. One bottle is dirt cheap, only 13 Euro.

    Studies:
    https://www.ncbi.nlm.nih.gov/pubmed/24918436
    Contrasting short-term and long-term consequences of uridine on liver metabolism suggest that uridine exerts transient effects and elicits adaptive responses. Taken together, our data support potential roles of pyrimidines and their derivatives in the regulation of liver metabolism.
    https://www.ncbi.nlm.nih.gov/pubmed/24475249
    Our data indicates a therapeutic potential for uridine co-administration to prevent fenofibrate-induced fatty liver.
    https://www.ncbi.nlm.nih.gov/pubmed/26565787
    This study demonstrated that P. giganteus may enhance neurite outgrowth and one of the key bioactive molecules responsible for neurite outgrowth is uridine.
    https://www.ncbi.nlm.nih.gov/pubmed/28919465
    We show that uridine treatment reduces apoptotic cell death and hypomyelination while increasing the number of surviving neurons in hyperoxic pups on P5. In addition, uridine enhances learning and memory performances in periadolescent rats on P40. These data suggest that uridine administered during the course of hyperoxic insult enhances cognitive functions at periadolescent period probably by reducing apoptotic cell death and preventing hypomyelination during the neonatal period in a rat model of hyperoxia-induced brain injury.
    there are more studies but I think that should be enough for now.

    Note: I've not yet tested this product, but I'll order it. Despite the clear indication that uridine does have a positive effect on the brain I do not expect greatly noticeable results though. But considering the amount of debilitating neurodegenerative diseases such as Parkinson's disease or (early onset) Alzheimers, I'd say it can't hurt to try it.
    Solution for the rapefugee crisis https://www.youtube.com/watch?v=uTYkcnJdDio
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  2. #2
    Senior Member Aintdealingwithyoshit's Avatar
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    Re: [Lifestyle] Nootropics

    Uridine seems to also repair and enhance Dopamine receptors, thus potentially also improving mood and energy levels.
    This guy has made a pretty comprehensive video about it:


    I'm currently taking 500mg every day, in stack with 300mg Bacopa Monnieri (50% Bacosides).
    Solution for the rapefugee crisis https://www.youtube.com/watch?v=uTYkcnJdDio
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  3. #3
    Senior Member Aintdealingwithyoshit's Avatar
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    Re: [Lifestyle] Nootropics

    So small update ...
    I forgot to mention I also take Alpha GPC 300 mg and Huperzine A (+Ginkgo).
    I was taking the Alpha GPC and Huperzine A before I started taking Bacopa (which is 700mg, 50% Bacosides ... 300mg was wrong) and Uridine, but since I added Bacopa and Uridine I have noticed immediate effects: Significantly increased focus, energy and wellbeing. I am very impressed by this stack so far. Caffeine stacks wonderfully with this as well (I just drink 2-3 cups of coffee).

    Just wondering though, is the lack of replies due to a lack of interest or is there nobody who feels like he could contribute to this topic? If there's no interest in the subject matter, I'll stop posting about it, after all it then wouldn't be worth my effort.
    Solution for the rapefugee crisis https://www.youtube.com/watch?v=uTYkcnJdDio
    Politicians? Oh, you mean ​lamppost ornaments!

  4. #4
    Senior Member Azure Nomad's Avatar
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    Re: [Lifestyle] Nootropics

    I am surprised they are not using Uridine to treat drug addicts more widely. Unless they are already doing so it seems to be an easy way to solve a lot of drug addiction issues and also bipolar issues.

    I will have to look into it further. Thanks for the heads up!

  5. #5
    Senior Member Aintdealingwithyoshit's Avatar
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    Re: [Lifestyle] Nootropics

    Clonidine can be and is also used for addiction. It's normally a blood pressure medication, though not usually used for that purpose anymore. Interestingly Clonidine can also increase growth hormone secretion by quite a bit, though it is questionable whether this effect is permanent or will fall prey to body tolerance sooner or later.
    That said, Clonidine is a synthetic drug, whereas Uridine is a naturally occuring substance and can be found in beer, broccoli, tomatoes etc. However, the amount of uridine found in food and drinks is way too small to have any nootropic or addiction soothing impact. You will inevitably have to supplement it if you want to receive its benefits. But due to its natural occurence in numerous food and drinks I suppose the price is also quite low.

    I have now added KSM-66 (high potency Ashwaghanda) and Aniracetam to the stack as well. One difference I've noticed is more vivid dreams, I actually got a bit of "dream spill over" this morning and could see a wasp that I had just seen in my dream. Aniracetam has research chemical status and is thus legal even in Germoney, which has relatively strict laws regarding such substances. Structurally it is similar to the "mother of synthetic nootropics" Piracetam, but it has its own unique effects. Side effects are pretty much non-existent so far.

    Both Ashwaghanda and Bacopa Monnieri are so-called adaptogens. These substances have numerous positive effects on the body aside from "just" their nootropic benefits, such as Cortisol control, immune function support, hormonal homeostasis support etc.
    Solution for the rapefugee crisis https://www.youtube.com/watch?v=uTYkcnJdDio
    Politicians? Oh, you mean ​lamppost ornaments!

  6. #6
    Senior Member Aintdealingwithyoshit's Avatar
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    Re: [Lifestyle] Nootropics

    So I should get some Lion's mane mushroom as well soon. 200 grams cost a mere 24 € so that's fairly cheap. Dosage is 500 mg - 3 grams every day, not sure how much I'll take yet.
    Video about LMM
    Solution for the rapefugee crisis https://www.youtube.com/watch?v=uTYkcnJdDio
    Politicians? Oh, you mean ​lamppost ornaments!


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